LYNXSOFT
Work
  • Feb 2021 - Current
    Lynxsoft SRL
    Freelance Software Engineer & Scientific IT Consultant

    Independent software engineering and technical consulting services specializing in scientific computing, pharmacometrics software architectures, custom simulation tools, and full-stack technical solutions.

    Core Services & Capabilities

    • Scientific Software Engineering & Architecture: Designing modular, high-performance software systems for modeling & simulation pipelines and scientific data processing using R and Python.
    • PK/PD & Simulation Platform Development: Building domain-specific simulation frameworks, automated Non-Compartmental Analysis (NCA) toolkits, and multi-backend engine abstraction (such as mrgsolve and rxode2).
    • MIPD/TDM Software & In-Silico Trial Simulations: Developing Model-Informed Precision Dosing (MIPD) applications and conducting retrospective in-silico trial simulations to evaluate advanced dosing algorithms (e.g., Model Predictive Control) against clinical standard of care.
    • Pharmacometrics Modeling & Simulation Execution: Conducting population PK/PD simulation projects, scenario analyses, and clinical trial simulations for pharmaceutical and biotech clients.
    • Language Integration & API Design: Engineering language-agnostic JSON interfaces, REST APIs, and seamless inter-process communication between backend simulation engines and modern user interfaces.
    • Full-Stack & Desktop Application Development: Architecting interactive data platforms and standalone desktop tools using Shiny for Python, modern web front-ends, and desktop packaging solutions.
    • Reproducible Data Pipelines & Automation: Implementing structured, reproducible workflows and post-processing pipelines using tools like the R targets package.
    • Open-Source Maintenance & Extension: Developing, documenting, and extending CRAN/GitHub open-source ecosystems (such as S4/OOP-based R packages and simulation toolkits) following static typing and tidyverse standards.
  • Jan 2021 - 31/10/2026
    Calvagone (via Lynxsoft SRL)
    Senior Pharmacometrics Developer & IT Consultant

    Independent consulting engagement delivering specialized software engineering, open-source tool development, and IT architecture in modelling and simulation.

    Key Highlights & Technical Achievements

    • Campsis Suite Architecture: Lead developer and architect of the open-source Campsis suite (campsis, campsismod, campsisnca, campsismisc) built using S4 object-oriented R design and tidyverse standards for PK/PD modeling and clinical trial simulation.
    • Interoperability & JSON Interface: Engineered a language-agnostic JSON interface allowing external Python backends, desktop GUIs, and AI workflows to exchange structured simulation configurations seamlessly with the R engine.
    • e-Campsis Application: Built a standalone application platform combining a Shiny for Python front-end with an R Plumber API backend communicating over JSON to configure, execute, and visualize complex simulations.
    • Tacrolimus MIPD & In-Silico Trial Simulations: Reused and extended the open-source tdmore platform to evaluate novel Model Predictive Control (MPC) techniques for tacrolimus dosing in lung, heart, and bone marrow transplantation. Executed in-silico clinical trial simulations driven by retrospective patient data to benchmark MPC against standard of care (Transplantation; DOI: 10.1097/01.tp.0001251300.05695.75).
    • MIPD Application Development: Developed the software platform for Model-Informed Precision Dosing (MIPD) to optimize factor IX (rFIX-FP) administration in hemophilia B surgical patients, supporting published clinical PK research (Haemophilia, 2026; PMID: 42227215).
    • Workflow Automation: Migrated legacy simulation pipelines for pharmaceutical clients and established standardized, reproducible post-processing workflows using the R targets package.
    • Engine Integrations: Maintained compatibility with core PK/PD simulation engines (mrgsolve, rxode2), automated Non-Compartmental Analysis (NCA), and reporting integrations (gtsummary, gt).
  • Jan 2017 - Dec 2020
    SGS Exprimo
    IT Scientist (Modelling & Simulation)

    Developed modeling and simulation software, optimized simulation engines, and managed high-performance computing infrastructure for pharmacometrics workflows.

    Key Highlights & Technical Achievements

    • Simulo Platform Development: Developed and maintained Simulo, an advanced clinical trial simulation platform. Implemented NONMEM import plug-ins, C-compiled core execution modules for high-speed performance, and custom R post-processing tools.
    • Simulation Execution: Executed clinical trial simulations for extrapolation studies (adult to pediatric PK), optimal design evaluations via PopED, and dosing algorithm efficacy/safety assessments.
    • HPC Cluster Management: Administered Linux HPC cluster infrastructure supporting PK/PD modelers with NONMEM grid deployments and server administration.
  • Jan 2016 - Dec 2017
    itini
    Founder & Lead Developer

    Founded and engineered an independent mobile application and web platform for outdoor navigation and GPS tracking.

    Key Highlights & Technical Achievements

    • Engineered an Android navigation app featuring real-time 3D guidance and GPS track recording.
    • Developed the web service backend and published the app on the Google Play Store.
  • Jan 2014 - Dec 2017
    Infrabel (via Akka-Benelux)
    Project Leader — Mobile Equipment Testing App

    Led technical feasibility studies and software deployment to digitize railway equipment field testing for Belgium’s railway infrastructure manager.

    Key Highlights & Technical Achievements

    • Digitized manual railway signaling equipment testing workflows into tablet-based mobile applications.
    • Managed full software lifecycle: requirements analysis, tablet deployment, user training, and field support.
  • Jan 2012 - Dec 2014
    Infrabel (via Akka-Benelux)
    Software Engineer & Business Analyst — ETCS Tools

    Engineered automated signaling software tools for the European Train Control System (ETCS Level 1) across the Belgian railway network.

    Key Highlights & Technical Achievements

    • Built automated tools for track signaling data deployment using railML and XML interchange formats.
    • Authored functional software specifications, architecture documentation, and validation procedures.
  • Jan 2011 - Dec 2012
    Acapela Group
    Software Engineer — Voice Creation Platform

    Engineered web server software for synthetic voice generation and Text-to-Speech (TTS) processing.

    Key Highlights & Technical Achievements

    • Developed automated server-based systems for generating custom synthetic Text-To-Speech (TTS) voices through web browser interfaces (My Own Voice).